P222 Multi-central profile of refugee cystic fibrosis patients in Turkey

Cystic fibrosis (CF) is an autosomal recessive disease caused by cystic transmembrane regulator protein (CFTR) gene mutations. The incidence of CF varies considerably among different ethnic groups worldwide, although it most common in the Caucasian race. This study aims to examine clinical course and treatment refugee patients our country. A total 43 diagnosed with between March 2011–2022 applied five centers. Genetics profile, presenting symptoms, age at diagnosis, weight, height, BMI SDS follow-ups were noted, compared Turkish national registry (TNCFR) results. 43.5% (n = 23) male. average first application 24.3 months. mean diagnosis was 33.9 (22 days-156) 58.1% 25) had a history parental consanguinity. 97.6% 42) Syrian nationals. Mean 1. immunoreactive trypsinogen (IRT): 140 (92–280) ng/mL. second IRT: 103.75 (71–191) sweat chloride test 72.4 (6–109). Pseudomonas aeruginosa colonization detected 15.2% 7). reasons for hospitalization pseudobartter clinic, pulmonary exacerbation, eradication treatment. DF508 allele 25.7% 17) patients. After civil war 2011, millions Syrians shelter neighboring countries, primarily Turkey. In study, start receive later, their are lower, use doubtful. Health screening programs should be better organized, host countries do long-term planning early intervention, longer life expectancy. There need more extensive studies determine prevalence make its genetic evaluation.